Bicycle Therapeutics
cambridge
Full Time
Permanent
Bicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating zelenectide pevedotin (formerly BT8009), a Bicycle® Toxin Conjugate (BTC®) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC molecule targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist® (Bicycle TICA®) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle® Radio Conjugates (BRC™) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle® technology to develop therapies for diseases beyond oncology.
Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, Mass.
Culture is key and all Bicycle employees actively embrace and role model our company values:
We have an exciting opportunity for a Senior Scientist to join our Structural Biology Team: You will join a team dedicated to obtaining high-quality protein structural data to positively impact a wide range of drug discovery programs, both internal and partnered. The candidate activities will be related mainly to two methods: X-ray protein crystallography and Cryo-electron microscopy (CryoEM).
You will employ different structural methods to furnish insights into target biology and map protein-ligand interactions to power structure-guided drug design of our unique Bicycle® peptides. You will work closely with cross-functional project teams to generate impactful structural data that drives project success and scientific publications.
You will be highly-motivated, self-reliant with experience delivering, interpreting and validating structural data. Excellent technical expertise in structural biology methods and strong communication skills are essential.
Key responsibilities
Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.
Bicycle Therapeutics
cambridge
Full Time
Permanent